Nacetyl Lcarnitine Nootropics UK from Earthly Biotics

N-Acetyl L-Carnitine

ALCAR

N-Acetyl L-Carnitine (also known as ALCAR, ALC, or LAC) is a naturally occurring amino acid produced by your liver and kidneys. It is then transported to other parts of the body, including the heart and the brain, where it easily crosses the blood-brain barrier, unlike standard L-Carnitine. ALCAR has the metabolic effects of L-Carnitine, but has the added advantage of a number of cognitive functions, as it can cross the blood-brain barrier.

N-Acetyl L-Carnitine can also be obtained by eating red meat and dairy. It is considered conditionally essential for healthy living, and when your body uses it faster than it can produce it which is recurring if physically training, you need supplemental L-Carnitine either from food or a natural supplement.

 

History

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Since their discovery, L-Carnitine and Acetyl-L-Carnitine have often been confused with one another. Both are frequently referred to as Carnitine. However, each is structurally different.

L-Carnitine provides energy for your cells, but is not capable of crossing the blood-brain barrier. L-Carnitine is used by athletes and dieters who wish to access Carnitine’s fat-burning, endurance & power output properties, but are not seeking its cognitive benefits.

Acetyl-L-Carnitine is easier for the body to absorb and use. One study showed that 50 days of using just 2 grams boosted blood ALCAR levels by 43%. It is important to note the ALCAR retains many benefits of normal L-Carnitine along with its cognitive attributes. [source:1].

Researchers have also found that while L-Carnitine has no protective qualities for the brain, ALCAR does [source:2]. Seeming as ALCAR retains benefits of L-Carnitine, it is generally considered superior.

 

Benefits

The principal health benefits of ALCAR can be summarized as follows: 

  • Increases Brain Energy & Performance
  • Slows Rate of Cognitive Decline
  • Reduce Muscle Damage & Increased Muscle Recovery
  • Increased Power Output & Muscle Fuel Metabolism
  • Effective For Chronic Fatigue Syndrome
  • Improved Attributes Related to Sex

 

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Increases Brain Energy & Performance

 ALCAR promotes brain energy by fuelling your brain cells‘ mitochondria [source:3]. Boosting your cells’ “power plants” can improve physical and mental energy.

ALCAR shuttles fatty acids through cell membranes, right into the mitochondria [source:4], thus providing the fuel that is burned for energy. It also flushes toxic byproducts out of the mitochondria. This dual function keeps cells healthy, and with the brain in particular creating a lot of toxic byproducts, ALCAR is especially important for a healthy brain to be optimised and working at an improved rate.

Not only does ALCAR contain a more efficient Carnitine, it also has Acetyl-moieties, both of which have neurobiological properties. The main benefits being brain energy, metabolism, the functioning & turnover of proteins, and acting as a chaperone for larger molecules allowing faster transmission process. [source:5]

Acetyl-L-Carnitine also boosts neurotransmitter acetylcholine, which is associated with overall brain function, cognitive performance & memory. [source:6].

 

Slows Rate of Cognitive & Age Related Decline

In a year-long study, 130 Alzheimer’s patients were given ALCAR or a placebo every day. In 14 areas of cognitive performance, those who had taken the ALCAR showed a slower rate of decline when compared to the placebo group [source:7].

Source : 12

Source : 12

Brains affected by Alzheimer’s disease show a 25% to 40% reduction in the enzyme carnitine acetyltransferase. This brain enzyme decline led scientists to link low ALCAR with low acetylcholine, and thus to Alzheimer’s onset. ALCAR is now being considered as a viable therapy for brain regeneration. [source:8]

Another study conducted in mild cognitive impairment and early Alzheimers was showed significant  advantage for ALCAR. The test was carried out over 12 months with results monitored at multiple stages and a placebo group put in place. [source:9]

The relationship that Acetyl L-Carnitine has with deterring cognitive decline is continually documented alongside it’s benefits for performance. Synaptic energy state and mitochondrial dysfunction are crucial factors in many brain pathologies. Known to improve brain energy metabolism, it has been proposed for the therapy of many neurological and psychiatric disorders such as Dementia & Depression. [source:10] [source:11]

It is also believed that ALCAR can benefit sufferers of Parkinson’s Disease. Research at the Mount Sinai School of Medicine in New York showed that ALCAR directly affects mitochondrial respiration and improves the use of dopamine in the brain, thus relieving Parkinson’s symptoms.

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Further to the benefits of supplementing with this powerful naturally occurring amino acid was a 2012 study, rather comprehensive in it’s substance, that saw it tackle age-related decline in Carnitine-palmitoyltransferase. As you get older the ageing heart displays a loss of bioenergetic reserve capacity partially mediated through lower fatty acid utilisation. Myocardial Carnitine levels decline with age but can be partially restored by dietary supplementation with acetyl-L-carnitine. Therefore not only does it treat age related cognitive diseases, but the potential for also your heart. [source:12]

 

Reduce Muscle Damage & Increased Muscle Recovery

Two studies conducted a year apart lasted for 2-4 weeks, and had 10 subjects between the ages of 18-29. They both showed that L-Carnitine supplementation favourably affects markers of recovery from physical training stress, in these cases they especially show it positively in resistance training. [source:13] [source:14]

The physical effects for L-Carnitine are just as prevalent in middle aged people as younger. Being able to reduce physical fatigue and increase recovery rates. A study was conducted for over 3 weeks as a double blind placebo controlled structure. It’s findings support previous findings of l-carnitine in younger people that such supplementation can reduce chemical damage to tissues after exercise and optimize the processes of muscle tissue repair and remodeling. [source:15]

 

Source : 16

Source : 16

Increased Power Output & Muscle Fuel Metabolism

Many studies have been conducted on the abilities for Carnitine variations to increase power output and the more comprehensive the study, the more positive the results. One such trial successfully showed with supplementation an enhanced anaerobic work capacity with reduced lactate accumulation. Primarily conducted through looking at the performance of repeated high intensity sprints with limited recovery periods, they cited significant main effects, with values across the five sprint bouts being 15% greater with L-Carnitine, along with 16.2% lower lactate. [source:16] 

Further to power output of supplementing with carnation variations, we can also see the effects of exercise metabolism and performance in people. In 3 stages over a 12 week period, 14 participants took part in performing 30 minutes of exercise at 50%, 80%, and then an ‘all out’ work output performance trial. They were subject to ingestion of L-Carnitine in a double blind placebo controlled manner.

Source : 17

Source : 17

The results speak for themselves that dietary supplementing with Carnitine can have a profound effect. “At 50% , the Carnitine group utilised 55% less muscle glycogen compared to Control”. Going on to cite “The Carnitine group increased work output 11% from baseline in the performance trial, while Control showed no change.”.
Clear enough for the paper to conclude it as a demonstration that human muscle total Carnitine can be increased by dietary means and the changes were associated with an improvement in exercise performance. [source:17] 

 

Effective For Chronic Fatigue Syndrome

Acetyl-L-Carnitine has improved the symptoms of people suffering from chronic fatigue syndrome. A recent trial compared a group of 36 patients who were treated for 3 months with either amantadine (used to treat chronic fatigue), or 1 gram of ALCAR twice daily.

The randomized, double-blind, crossover study showed that ALCAR was better tolerated and more effective than the pharmaceutical for chronic fatigue syndrome [source:18].

 

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Improved Attributes Related to Sex

Results of this highlighted study indicated that the Propionyl-L-Carnitine/ALCAR combination was better than testosterone for erectile dysfunction, and the ALCAR cohort reported better orgasms, more sexual desire and improved mood. 120 patients were divided into 3 groups.  The 3 groups were either given a daily dose of testosterone, or of Propionyl-L-Carnitine and Acetyl-L-Carnitine, or a placebo. Further, the Propionyl-L-Carnitine/ALCAR did not produce the side effects of testosterone, such as an enlarged prostate [source:19].

 

Side Effects

Acetyl-L-Carnitine is naturally occurring in the body and is therefore considered safe and is generally well-tolerated. Rare side effects can include restlessness, increased agitation, vomiting, nausea and weight loss. Those suffering from seizure disorders may also experience an increase in seizure frequency.

 

 

This information should be used for guidance only, please consult with a medical professional before taking any dietary supplement. Should you suffer from any ongoing medical conditions or have any concerns at all, consult your doctor in the first instance.

 

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References

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