Lalpha GPC as Smart Drugs in Global Focus Nootropics by Earthly Biotics

L-Alpha GPC

Choline Alfoscerate / glycerylphosphorylcholine

Alpha-GPC (L-Alpha Glycerylphosphorylcholine, choline alfoscerate) is a source of choline that can be derived from sunflower and soy lecithin. It is  found in small quantities within the human body, but deficiency is common as it is not prevalent in the average diet. Choline is a nutrient vital to nerve function and overall cognition, which is key for the production of acetylcholine, and phosphatidylcholine (PC) one of the building blocks of cell membranes.

Alpha-GPC is water soluble, allowing it to cross the blood-brain barrier quickly after entering the system, making it highly bioavailable. It is also a very choline-rich precursor, at 40% content by weight. 

Alpha-GPC is present in the creation of acetylcholine, an essential neurotransmitter for focus, memory, learning and overall brain function. It occurs naturally in the brain as a byproduct of phosphatidylcholine (PC), but regularly in our daily lives supplies start to drop, and the brain needs choline, cell membranes get broken down to extract PC, in order to create more Alpha-GPC. For this reason, supplementing with Alpha CPC is fantastic for your brain and body as it removes the need for cell cannibalization. Allowing for continuously improved daily brain function no matter the mental intensity.

 

Benefits

L-Alpha GPC has many joint benefits, the strongest and most significant of which we will discuss are:

  • Improves Focus & Cognitive Processing Speed
  • Boosts Learning & Memory
  • Strength, Power, & Lean Muscle Mass
  • Boosts Dopamine
  • Brain Health Protection

 

Improves Focus & Cognitive Processing Speed

As a neurotransmitter acetylcholine - a product of Alpha-GPC - improves the communication process between neurons, cognitive processing speed & mental clarity.

In a study of 32 healthy volunteers, Alpha-GPC was tested for its affects on attention & concentration. The participants were given either Alpha-GPC or a placebo and after 10 days they were given scopolamine, an amnesia inducer. The results found that Alpha-GPC prevented the impairments associated with amnesia and loss of concentration when compared to the control group. [source:1] The findings suggest that sustained focus, communication, and memory function, even in healthy young people, can be improved by supplementing Alpha-GPC.

L-Alpha GPC also develops cell membranes, which are the outermost layer of neural tissue, responsible for processing information, controlling intelligence, motor function, personality, and planning - to name a few! [source:2] [source:3]

The ingredient of L-alpha GPC is consistently found to be a strong and useful way to improve cognitive mechanisms through an involvement of central neurotransmission. [source:4]

 

Boosts Learning & Memory

Improvements in memory formation and enhanced learning are the main benefits of taking an Alpha-GPC supplement, both for healthy adults and the ageing population facing cognitive decline.[source:5] The function which precipitates this is the brain’s hippocampus using acetylcholine to produce memories. Through various trials on human participants, it has been found that these enhancements in memory formation can improve a persons ability to focus, learn and retain information. As well as counter a range of ageing brain disorders such as Alzheimer’s Disease, Vascular Dementia and Stroke. [source:6][source:7][source:8]

One study on attention and memory found that Alpha-GPC also enhances the effectiveness of donepezil (acetylcholinesterase inhibitor) when compared to using donepezil in isolation. In rats, Alpha-GPC was found to enhance brain enerrgy mechanisms and protect against age-related structural changes in the brain, resulting in boosts to memory and learning. [source:9] [source:10]

A review of thirteen clinical trials, with a total of 4054 participants showed that Alpha-GPC consistently: [source:11]

  • Improved memory and attention
  • Aided quicker recovery in stroke patients
  • Reversed symptoms brought on by acute cerebrovascular disease

Furthermore, choline itself aids brain elasticity by modulating acetylcholine levels, which decline naturally as the body ages. [source:12] In fact some studies have found reason to believe that low levels of acetylcholine may actually be what causes cognitive decline in the first place, with strong correlations being found between the development of Alzheimer’s Disease and very low acetylcholine levels.[source:13][source:14]

 

Source : 15

Source : 15

Strength, Power & Lean Muscle Mass

Professional sporting athletes often supplement Alpha-GPC as it is a completely natural way for strengthening & increasing lean muscle mass, providing more energy when training, and aiding quicker recovery. Not only does Alpha-GPC boost brain function, it also increases physical strength. A study recorded a power output increase of up to 14% in cases where Alpha-GPC was taken 45 minutes prior to a training session. [source:15]

Alpha-GPC is also an asset to athletes due to the way it works in pituitary glands, boosting the natural production of the muscle growth hormone. This increase improves cell growth, repair and reproduction, which in turn aids muscle recovery, power, strength and the building of lean muscle mass. [source:16]

Additional physiological benefits also include helping to restore and improve nerve growth factor receptors. The cerebellar cortex represents an interesting model for the analysis of age-dependent changes in brain micro-anatomy and function. Further, the cerebellar cortex contains detectable amounts of nerve growth factor (NGF) and express NGF receptors, which are sensitive to ageing. Keep your nerve receptors young and healthy to stay as physically capable as possible when getting older. [source:17]

 

Brain Health Protection

Choline-containing phospholipids were proposed as cognition enhancing agents, but evidence on their activity is controversial. CDP-choline (cytidine-5´-diphosphocholine, CDP) and choline alphoscerate (L-alpha-glycerylphosphorylcholine, GPC) represent the choline-containing phospholipids with larger clinical evidence in the treatment of sequelae of cerebrovascular accidents and of cognitive disorders. These compounds which display mainly a cholinergic profile interfere with phospholipids biosynthesis, brain metabolism and neurotransmitter systems. [source:18]

A study published in Clinical Therapeutics conducted a placebo-controlled, double-blind trial on patients with mild to moderate Alzheimer’s. The participants were given Alpha-GPC three times daily for 180 days. At the end of the trial, it was concluded that Alpha-GPC made consistent improvements in dementia patients.  [source:19]

 

Boosts Dopamine

Alpha-GPC has been found to promote the release of dopamine, a hormone and neurotransmitter responsible for mood, motivation attention and regulating body movements. This may well lead to possible treatments for mood/depressive disorders and neurodegenerative conditions. [source:20][source:21]

Studies have also shown that Alpha-GPCs impact on dopamine production can be beneficial for reducing anxiety. [source:22]

 

Side Effects

While clinical trials have demonstrated that adults can tolerate Alpha-GPC in higher than recommended quantities, the overuse of the supplement can result in side-effects such as headaches or dizziness.

 

 

This information should be used for guidance only, please consult with a medical professional before taking any dietary supplement. Should you suffer from any ongoing medical conditions or have any concerns at all, consult your doctor in the first instance.

 

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